The National Shrine of Our Lady of the Miraculous Medal is 80 miles south of St. Louis, Missouri, on Interstate 55. To reach the Shrine, take the Perryville exit (No. 129) and turn left onto Highway 51 to go toward Perryville. At the junction of State Road “T” (St. Joseph Street) turn left. After passing Progress Drive, the Shrine’s entrance is the third drive on the left. (1805 W St. Joseph St., Perryville, Missouri 63775)

Approaching from the east (Illinois) follow State Highway 51 to the junction of State Road “T” (St. Joseph Street) and turn right.